Publications                                                                                                   

Shaoying Tan†, Deheng Sun†, Jiankun Lyu†, Xiao Sun, Fangshu Wu, Qiang Li, Yiqi Yang, Jianxu Liu, Xin Wang, Zhuo Chen^*, Honglin Li^*, Xuhong Qian, Yufang Xu^*. Antiproliferative and apoptosis-inducing activities of novel naphthalimide–cyclam conjugates through dual topoisomerase (topo) I/II inhibition. Bioorgan. Med. Chem. 2015, 23(17), 5672-5680, doi:10.1016/j.bmc.2015.07.011

Deheng Sun^‡, Yu Yang^‡, Jiankun Lyu^‡, Wei Zhou, Wenlin Song, Zhenjiang Zhao, Zhuo Chen^*, Yufang Xu^*, and Honglin Li^*. Discovery and rational design of pteridin-7(8H)-one-based inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants. J. Med. Chem. 2016, 59(13): 6187-6200, doi:10.1021/acs.jmedchem.6b00374

Yongjia Hao^†, Jiankun Lyu^†, Rong Qu^†, Deheng Sun, Zhenjiang Zhao, Zhuo Chen, Jian Ding, Hua Xie^*, Yufang Xu^*, Honglin Li^*. Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors. Sci. Rep., 2017, 7 : 3830.

Yongjia Hao^†, Jiankun Lyu^†, Rong Qu^†, Yi Tong, Deheng Sun, Fang Feng, Linjiang Tong, Tingyuan Yang, Zhenjiang Zhao, Lili Zhu, Jian Ding, Yufang Xu^*, Hua Xie^*, Honglin Li^*. Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H, 3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation. J. Med. Chem., 2018, 61 (13), 5609-5622.

Qiao Li^†, Lina Quan^†, Jiankun Lyu, Zenghui He, Xia Wang, Jiajia Meng, Zhenjiang Zhao, Lili Zhu^*, Xiaofeng Liu^*, Honglin Li^*. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor. Oncotarget, 2016, 7 : 64967-64976.

Yi Tong^†, Qian Jiao^†, Yuanru Liu, Jiankun Lyu, and Rui Wang^* and Lili Zhu^*. Maprotiline Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats. Front. Pharmacol., 2018, 9 : 1032.