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Result of 161018113843

Top 300 targets ranked by normalized fit score in descending order

Ligand: tamoxifen
Rank PDB ID Target Name Number of Feature Fit Score Normalized Fit Score z'-score

  +          

1 Thyroid hormone receptor beta 3 2.994 0.9979 -0.348409

  +          

2 Estrogen-related receptor gamma 6 5.736 0.956 4.32345

  +          

3 Estrogen-related receptor gamma 6 5.735 0.9559 4.449

  +          

4 Glutathione reductase, mitochondrial 4 3.801 0.9502 1.42504

  +          

5 Estrogen-related receptor gamma 6 5.673 0.9454 4.15498

  +          

6 Estrogen receptor 6 5.668 0.9447 4.02161

  +          

7 Transthyretin 4 3.738 0.9344 1.17142

  +          

8 Estrogen-related receptor gamma 6 5.568 0.9281 4.10546

  +          

9 Transthyretin 5 4.623 0.9246 2.70553

  +          

10 Estrogen-related receptor gamma 6 5.497 0.9162 3.94299

  +          

11 Estrogen receptor beta 6 5.492 0.9154 4.00341

  +          

12 Estrogen receptor 6 5.467 0.9112 3.88546

  +          

13 Estrogen receptor 5 4.553 0.9106 2.61317

  +          

14 Proto-oncogene serine/threonine-protein kinase Pim-1 4 3.641 0.9102 1.00572

  +          

15 Progesterone receptor 4 3.391 0.8478 0.541913

  +          

16 Liver carboxylesterase 1 4 3.344 0.8361 0.360266

  +          

17 Estrogen-related receptor gamma 7 5.643 0.8061 3.8901

  +          

18 Estrogen receptor 7 5.634 0.8048 3.75114

  +          

19 Estrogen receptor 6 4.752 0.7921 2.62785

  +          

20 Estrogen receptor 5 3.907 0.7813 1.59365

  +          

21 Estrogen-related receptor gamma 6 4.68 0.78 2.44111

  +          

22 Estrogen-related receptor gamma 4 3.057 0.7642 -0.188337

  +          

23 Estradiol 17-beta-dehydrogenase 1 5 3.717 0.7433 0.88154

  +          

24 Cytochrome P450 51 4 2.971 0.7427 -0.463756

  +          

25 Estrogen receptor 4 2.961 0.7403 0.122988

  +          

26 Estrogen receptor 5 3.696 0.7393 1.01332

  +          

27 Cationic trypsin 5 3.632 0.7265 1.0687

  +          

28 Estrogen-related receptor gamma 5 3.604 0.7209 0.802572

  +          

29 Estrogen receptor beta 5 3.601 0.7203 0.799582

  +          

30 Estrogen receptor 7 5.014 0.7163 3.1472

  +          

31 NAD(P)H dehydrogenase [quinone] 1 5 3.427 0.6855 0.379821

  +          

32 Estrogen receptor 6 4.105 0.6842 1.69124

  +          

33 Prostaglandin G/H synthase 2 5 3.411 0.6822 0.308482

  +          

34 Estrogen receptor 6 3.981 0.6635 1.5787

  +          

35 Nuclear receptor ROR-beta 6 3.897 0.6496 0.542633

  +          

36 Estrogen receptor 8 5.178 0.6473 2.50797

  +          

37 Sorbitol dehydrogenase 5 3.212 0.6425 -0.3714

  +          

38 Biphenyl-2,3-diol 1,2-dioxygenase 6 3.789 0.6315 1.08611

  +          

39 NONE 5 3.12 0.6241 -0.754599

  +          

40 Thymidylate synthase 6 3.721 0.6201 0.913817

  +          

41 Estrogen receptor 6 3.665 0.6109 1.01994

  +          

42 Estrogen receptor 6 3.664 0.6107 0.984253

  +          

43 Estrogen receptor 7 4.266 0.6095 1.75195

  +          

44 Estrogen receptor 6 3.634 0.6056 0.861567

  +          

45 Progesterone receptor 6 3.592 0.5986 0.589212

  +          

46 NONE 5 2.985 0.597 -0.525015

  +          

47 Estrogen receptor 6 3.582 0.5969 0.851553

  +          

48 Histone deacetylase 8 5 2.979 0.5958 -0.801607

  +          

49 Proto-oncogene tyrosine-protein kinase Src 5 2.979 0.5958 0.0462423

  +          

50 Androgen receptor 6 3.573 0.5955 0.723986

  +          

51 NONE 5 2.977 0.5954 -0.731777

  +          

52 NONE 5 2.977 0.5953 -0.245033

  +          

53 Anionic trypsin-2 5 2.976 0.5952 -0.963674

  +          

54 NONE 5 2.976 0.5952 -0.47812

  +          

55 Cell division protein kinase 2 5 2.975 0.595 -0.483036

  +          

56 Scytalone dehydratase 5 2.97 0.5941 -1.03948

  +          

57 Nitric oxide synthase, endothelial 5 2.962 0.5924 -0.214917

  +          

58 Chalcone--flavonone isomerase 1 5 2.961 0.5922 -0.379285

  +          

59 Estrogen receptor 6 3.538 0.5897 0.828089

  +          

60 NONE 6 3.53 0.5884 0.519145

  +          

61 Cell division protein kinase 2 6 3.496 0.5827 0.45226

  +          

62 NONE 6 3.479 0.5798 0.486549

  +          

63 Cationic trypsin 6 3.42 0.57 0.253714

  +          

64 Thyroid hormone receptor beta 6 3.404 0.5674 0.190069

  +          

65 Tyrosine-protein kinase ITK/TSK 6 3.391 0.5652 -0.206476

  +          

66 METHOXY MYCOLIC ACID SYNTHASE 2 MMAA2 6 3.389 0.5648 -0.346875

  +          

67 Thyroid hormone receptor alpha 7 3.941 0.5629 0.605077

  +          

68 Proto-oncogene tyrosine-protein kinase LCK 6 3.368 0.5613 -0.169155

  +          

69 Gag-Pol polyprotein 6 3.356 0.5593 0.210285

  +          

70 NONE 7 3.879 0.5542 0.928044

  +          

71 Estrogen receptor 6 3.321 0.5535 0.123032

  +          

72 Tyrosine-protein kinase JAK3 6 3.283 0.5472 -0.324636

  +          

73 2,2-dialkylglycine decarboxylase 7 3.789 0.5413 1.10828

  +          

74 Dihydrofolate reductase 7 3.777 0.5396 -0.194392

  +          

75 Cell division protein kinase 2 6 3.236 0.5394 -0.00413393

  +          

76 Estrogen receptor 8 4.311 0.5389 1.47643

  +          

77 Aldo-keto reductase family 1 member C3 7 3.771 0.5387 -0.215044

  +          

78 Dihydrofolate reductase 6 3.225 0.5375 -0.240218

  +          

79 Biotin carboxylase 6 3.224 0.5373 -0.145396

  +          

80 Cytidine deaminase 6 3.187 0.5312 -0.240043

  +          

81 Thyroid hormone receptor beta 7 3.713 0.5305 0.497211

  +          

82 Thyroid hormone receptor beta 7 3.708 0.5298 0.568021

  +          

83 Thyroid hormone receptor beta 7 3.699 0.5284 0.537968

  +          

84 Thyroid hormone receptor beta 7 3.69 0.5271 0.584488

  +          

85 Cell division protein kinase 2 6 3.162 0.5271 0.309677

  +          

86 cAMP-specific 3,5-cyclic phosphodiesterase 4D 6 3.143 0.5238 -0.77086

  +          

87 Mitogen-activated protein kinase 14 6 3.137 0.5228 -0.101603

  +          

88 Thyroid hormone receptor beta 7 3.646 0.5208 0.429168

  +          

89 Glycogen synthase kinase-3 beta 7 3.602 0.5146 0.688776

  +          

90 Estrogen receptor beta 6 3.083 0.5139 -0.127107

  +          

91 Estrogen receptor 8 4.099 0.5124 1.31017

  +          

92 Thyroid hormone receptor beta 7 3.58 0.5114 0.196696

  +          

93 Fatty acid-binding protein, heart 7 3.573 0.5105 -0.224855

  +          

94 Glutathione S-transferase A1 6 3.048 0.5079 -0.853367

  +          

95 Thyroid hormone receptor beta 7 3.526 0.5036 0.526419

  +          

96 Nitric oxide synthase, endothelial 6 3.022 0.5036 -0.633583

  +          

97 Acyl-CoA thioesterase 2 6 3.008 0.5014 -1.03191

  +          

98 Cell division protein kinase 2 6 2.998 0.4997 -0.739541

  +          

99 Nitric oxide synthase, endothelial 6 2.995 0.4992 -0.669173

  +          

100 Cell division protein kinase 2 6 2.995 0.4991 -0.352478

  +          

101 Aromatic-L-amino-acid decarboxylase 6 2.99 0.4984 -0.13368

  +          

102 Estrogen receptor 7 3.488 0.4983 0.053522

  +          

103 cAMP-specific 3,5-cyclic phosphodiesterase 4D 6 2.99 0.4983 -0.930831

  +          

104 Camphor 5-monooxygenase 6 2.989 0.4982 -1.10704

  +          

105 GFP-like fluorescent chromoprotein FP538 6 2.989 0.4982 -0.769563

  +          

106 Androgen receptor 6 2.989 0.4981 -0.842405

  +          

107 Bifunctional dihydrofolate reductase-thymidylate synthase 6 2.988 0.498 -0.814972

  +          

108 Integrin alpha-L 6 2.987 0.4979 -0.887744

  +          

109 Dihydrofolate reductase 6 2.987 0.4978 -0.72585

  +          

110 Mitogen-activated protein kinase 14 6 2.983 0.4971 -0.926177

  +          

111 Aspartate aminotransferase, mitochondrial 6 2.982 0.4971 -0.837229

  +          

112 Androgen receptor 6 2.981 0.4968 -0.861843

  +          

113 NONE 6 2.979 0.4966 -0.77423